Lateralized effect of rapid-rate transcranial magnetic
stimulation of the prefrontal cortex on mood.
( Efecto lateralizador de la EMTr sobre el estado de animo
en la Corteza Prefrontal.)
Pascual-Leone A, Catalá MD,
Departamento de Fisiología, Universidad de Valencia, Spain.
We studied the effects of rapid-rate transcranial magnetic
stimulation (rTMS) of different scalp positions on mood. Ten normal
volunteers rated themselves before and after rTMS on five
analog scales labeled "Tristeza" (Sadness), "Ansiedad"
(Anxiety), "Alegria" (Happiness), "Cansancio"
(Tiredness), and "Dolor/Malestar" (Pain/Discomfort).
rTMS was applied to the right lateral prefrontal, left prefrontal, or
midline frontal cortex in trains of 5 seconds' duration at 10
Hz and 110% of the subject's motor threshold intensity.
Each stimulation position received 10 trains separated by a
25-second pause. No clinically apparent mood changes were evoked
by rTMS to any of the scalp positions in any subject. However, left
prefrontal rTMS resulted in a significant increase in the Sadness
ratings (Tristeza) and a significant decrease in the Happiness
ratings ("Alegria") as compared with right prefrontal
and midfrontal cortex stimulation. These results show differential effects
of rTMS of left and right prefrontal cortex stimulation on mood and
illustrate the liberalized control of mood in normal volunteers.
– ANSIEDAD - ALEGRIA - CANSANCIO - DOLOR/ MALESTAR
Se visualiza una
importante disminución en las puntuaciones de la escala de Hamilton
y de Beck