EFECTO LATERALIZADOR DE LA EMTr

Lateralized effect of rapid-rate transcranial magnetic stimulation of the prefrontal cortex on mood.
( Efecto lateralizador  de la EMTr sobre el  estado de animo en  la Corteza Prefrontal.)

Pascual-Leone A, Catalá MD,
Departamento de Fisiología, Universidad de Valencia, Spain.

We studied the effects of rapid-rate transcranial magnetic stimulation (rTMS) of different scalp positions on mood. Ten normal volunteers rated themselves before and after rTMS on five analog scales labeled "Tristeza" (Sadness), "Ansiedad" (Anxiety), "Alegria" (Happiness), "Cansancio" (Tiredness), and "Dolor/Malestar" (Pain/Discomfort). rTMS was applied to the right lateral prefrontal, left prefrontal, or midline frontal cortex in trains of 5 seconds' duration at 10 Hz and 110% of the subject's motor threshold intensity. Each stimulation position received 10 trains separated by a 25-second pause. No clinically apparent mood changes were evoked by rTMS to any of the scalp positions in any subject. However, left prefrontal rTMS resulted in a significant increase in the Sadness ratings (Tristeza) and a significant decrease in the Happiness ratings ("Alegria") as compared with right prefrontal and midfrontal cortex stimulation. These results show differential effects of rTMS of left and right prefrontal cortex stimulation on mood and illustrate the liberalized control of mood in normal volunteers.

ESCALA VISUO-ANALÓGICA

TRISTEZA – ANSIEDAD -  ALEGRIA -  CANSANCIO -  DOLOR/ MALESTAR

 

 

 

 

 

 

 

 

 

 

Se visualiza una importante disminución en las puntuaciones de la escala de Hamilton y de Beck

 

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